Epigenetic obstacles encountered by transcription factors: reprogramming against all odds
نویسندگان
چکیده
منابع مشابه
Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.
Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to pr...
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Input from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induc...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2012
ISSN: 0959-437X
DOI: 10.1016/j.gde.2012.08.002